Sepsis- associated liver injury
Conditions
Interventions
Sepsis-associated liver injury group:None
Non-sepsis-associated liver injury group:None
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-80 years; Weight >=40kg and <= 100kg; 2) Septic patients admitted to the emergency ward and EICU from October 2025 to September 2028; 3) Sepsis should be diagnosed according to sepsis3.0;
Exclusion criteria
Exclusion criteria: 1) Consent cannot be secured from participants or their legally authorized representatives. 2) Patients or their agents opt to forgo treatment (exception: patients will not be excluded if they are willing to receive all supportive treatments except for resuscitation attempts in the event of cardiac arrest). 3) Moribund patients with an anticipated survival time of less than 24 hours. 4) Patients with potential malignant tumors or other diseases, with an estimated life expectancy of less than one month. 5) Currently suffering from alcohol dependence. 6) Patients with a previous history of liver cirrhosis (regardless of the cause). 7) Recipients of liver transplants. 8) Patients undergoing long-term dialysis. 9) Recipients of kidney transplants. 10) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of liver injury in sepsis; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28 day all-cause mortality;Duration of vasoactive drugs;Duration of mechanical ventilation;Duration of renal replacement therapy;Length of stay in ICU;Total length of stay; | — |
Countries
China
Contacts
Public ContactYi Han
Zhongshan Hospital Affiliated to Fudan University, Shanghai
Outcome results
None listed