Postoperative Pain After Abdominal Tumor Surgery
Conditions
Interventions
The Oliceridine Group:Analgesic pump drug preparation: Oxycodone 0.4 mg/kg diluted with normal saline to 100 ml. Analgesic pump parameters: background infusion 2 ml/h, bolus 2 ml per press, lockout ti
The Sufentanil Group:Pain pump drug preparation: Sufentanil 2 µg/kg diluted with saline to 100 ml. Pain pump settings: background infusion 2 ml/h, single press 2 ml, lockout time 15 minutes, maximum d
Sponsors
Jingzhou Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 65 years old; 2. Disease diagnosis: Benign and malignant abdominal tumors requiring surgical treatment (such as gastric cancer, liver cancer, rectal cancer, uterine fibroids); 3. ASA classification: I, able to tolerate anesthesia and surgery; 4. Informed consent: Patient or legal guardian signs a written informed consent form; 5. Patient awareness: Able to correctly understand and cooperate with postoperative patient-controlled analgesia procedures and assessments, able to clearly express pain levels, and understand how to use the analgesia pump.
Exclusion criteria
Exclusion criteria: 1. Cognitive or communication impairments: such as dementia, mental illness, or language disorders, making it impossible to cooperate with the assessment. 2. Drug-related contraindications: (1) History of allergy to Oseltamivir; (2) History of abuse of opioids or other psychoactive substances (such as morphine, pethidine, diazepam, etc.); 3. Severe comorbidities: (1) Uncontrolled cardiovascular disease (e.g., heart rate <50 bpm, systolic blood pressure <90 mmHg); (2) Liver or kidney dysfunction (Child-Pugh class C or eGFR <30 mL/min); (3) Severe respiratory disease (requiring mechanical ventilation or oxygen dependence); 4. Other exclusion factors: (1) Emergency surgery (requiring immediate intervention, making preoperative medication administration impossible); (2) Pregnant or breastfeeding women (potential risk to the fetus); (3) Undergoing combined surgery other than abdominal surgery, or experiencing severe complications during surgery (such as massive hemorrhage, malignant hyperthermia, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dynamic (during activity) and static (at rest) Numeric Rating Scale (NRS) scores at 4, 8, 12, 24, 48, and 72 hours postoperatively.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay Sedation Score at 4, 8, 12, 24, 48, and 72 hours postoperatively.;Quality of Recovery-15 (QoR-15) score at 72 hours postoperatively.;Incidence of rescue analgesia and adverse events (such as nausea, vomiting, respiratory depression, etc.) within 72 hours postoperatively.; | — |
Countries
China
Contacts
Public ContactZhang Kun
Jingzhou Central Hospital
Outcome results
None listed