Neurosyphilis (NSY)
Conditions
Interventions
Gold Standard:The diagnostic criteria for neurosyphilis based on CSF are as follows: 1. CSF protein level: >0.45 g/L
2. CSF white blood cell count: >5/µL (for HIV-positive untreated patients, white blood cell count >20/µL
for HIV-positive patients on antiretroviral therapy, with undetectable HIV viral load or CD4 T cell count 1:320.
Index test:Laboratory Testing of Cerebrospinal Fluid (CSF)
Sponsors
Shanghai Tongren Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age over 18 years; 2.Clinically diagnosed with neurosyphilis; 3.Complete clinical data available, including detailed medical history, cerebrospinal fluid (CSF) analysis, imaging studies, cognitive function assessments, and other multimodal data;
Exclusion criteria
Exclusion criteria: 1.Individuals unwilling to provide informed consent; 2.Individuals unable to independently complete the questionnaire;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic performance of the early diagnostic tool for neurosyphilis (score, sensitivity, specificity and AUC);Accuracy;Precision;Recall; | — |
Countries
China
Contacts
Public ContactYong Cai
Shanghai Tongren Hospital
Outcome results
None listed