Anesthesia, rapid sequential induction
Conditions
Interventions
remimazolam besylate group:Start sedation and analgesia with a combination of 0.3mg/kg remimazolam besylate combined with 1mg/kg rocuronium bromide, 1ug/kg remifentanil, and 1mg/kg lidocaine
propofol group:Start sedation and analgesia with a combination of 2mg/kg propofol combined with 1mg/kg rocuronium bromide, 1ug/kg remifentanil, and 1mg/kg lidocaine
Sponsors
Xiamen Hospital of Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Elective non-cardiac surgery patients; 2. Requiring endotracheal intubation for induction of general anaesthesia; 3. No gender restrictions, aged 18 to 65 years; 4. American Society of Anesthesiologists (ASA) physical status classification I–III; 5. Mallampati airway classification I–II; 6. Voluntary participation with signed informed consent; 7. Patients for whom rapid sequence induction (RSI) is clinically indicated during routine management, such as: those with full stomachs, intestinal obstruction, altered mental status, concomitant hiatal hernia, or requiring urgent surgery without adequate preoperative fasting.
Exclusion criteria
Exclusion criteria: 1. Individuals with respiratory tract infections within the past 14 weeks, or those using corticosteroids or bronchodilators; 2. Patients predicted to have difficult airways; 3. BMI >= 35 kg/m²; 4. Patients with myasthenia gravis, schizophrenia, or major depressive disorder; 5. History of allergy to opioid medications, propofol, or components of remimazolam (namely soybean oil, glycerol, triglycerides, egg yolk lecithin, sodium oleate, and sodium hydroxide).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of intubation conditions: excellent, good, poor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Post-Induction Hypotension;Sedation onset time;Initial Dose Induction Success Rate;Incidence of Injection Pain;Incidence of Postoperative Sore Throat;Use and Frequency of Use of Study Drug Supplementary Doses and/or Rescue Medications; | — |
Countries
China
Contacts
Public ContactHong Weifeng
Xiamen Hospital of Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed