postoperative nausea and vomiting
Conditions
Interventions
Granisetron Alone Group:None
Granisetron and Metoclopramide Group:None
Sponsors
Chengdu Seventh People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 87 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; 2. Surgical patients with an American Society of Anesthesiologists (ASA) physical status classification of II or higher, undergoing general anesthesia; 3. Postoperative Patient-Controlled Intravenous Analgesia (PCIA) with either of the following formulations: (1)Sufentanil 100 µg + Nalbuphine 50 mg + Granisetron 15 mg + Normal saline, total volume 200 ml; (2)Sufentanil 100 µg + Nalbuphine 50 mg + Granisetron 15 mg + Metoclopramide 20 mg + Normal saline, total volume 200 ml.
Exclusion criteria
Exclusion criteria: 1. History of diabetes mellitus, significant gastrointestinal diseases (e.g., gastroparesis, Crohn's disease, or ulcerative colitis), or prior major abdominal surgery. 2. Postoperative transfer to the Intensive Care Unit (ICU). 3. Requirement of additional opioid analgesics within 24 hours postoperatively. 4. Patients with missing postoperative follow-up data due to coma, severe dementia, language barriers, death, or any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative nausea and vomiting;Pain assessment; | — |
Countries
China
Contacts
Public ContactMengyue Gu
Chengdu Seventh People's Hospital
Outcome results
None listed