Hip Fracture
Conditions
Interventions
Non-frail patients:Remidazolam
Frail patients:Remidazolam
Sponsors
The First Affiliated Hospital of Shan Tou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective hip arthroplasty under combined spinal-epidural anesthesia; 2. Age>=18 years, regardless of gender; 3. ASA physical status classification of I to III; 4. BMI between 15 and 30 kg/m^2; 5. Written informed consent obtained from the patient or the patient's legal representative.
Exclusion criteria
Exclusion criteria: 1. Inability to complete the pre-operative Mini-Mental State Examination (MMSE) or an MMSE score below the threshold for the corresponding education level (No formal education: <=17; Primary school: <=20; Secondary school: <=22; University: <=23). 2. Pre-existing central nervous system diseases (including dementia, Parkinson's disease, or severe cerebrovascular disease with residual sequelae). 3. History of taking anxiolytic or antidepressant medication. 4. History of drug or alcohol dependence, or severe visual or hearing impairment. 5. Severe hepatic or renal dysfunction. 6. Severe respiratory or cardiovascular/cerebrovascular diseases. 7. Contraindications to neuraxial anesthesia (e.g., use of anticoagulant medications or coagulopathy, spinal diseases, patient refusal, etc.). 8. Known allergy to the drugs used in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective Sedation; | — |
Countries
China
Contacts
Public ContactZeting Qiu
The First Affiliated Hospital of Shan Tou University Medical College
Outcome results
None listed