Thalassemia
Conditions
Interventions
Pregnant women with NTDT iron supplementation group:Ferrous fumarate, 60 mg/day
Pregnancy with NTDT without iron supplementation group:Blank control
Normal pregnancy control group:Ferrous fumarate, 60 mg/day
Sponsors
Chongqing Health Center for Women and Children
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Those who voluntarily participate and complete informed consent; 2. Singleton pregnancy; 3. Patients with thalassemia confirmed by abnormal blood routine/hemoglobin and thalassemia gene detection; 4. Pregnant women with normal blood routine/hemoglobin; 5. Ferritin > 20µg/L; 6. Hb >=90 g/L; 7. Regular prenatal examination in our hospital can complete the follow-up;
Exclusion criteria
Exclusion criteria: 1. Refusal to participate; 2. Multiple pregnancy; 3. Pregnant women with systemic diseases (such as hypertension, diabetes, thyroid dysfunction, tumor, hepatitis, heart disease, etc.); 4. Thalassemia combined with iron deficiency anemia (Hb <110g/L, ferritin < 20µg/L); 5. Thalassemia patients with Hb < 90g/L who may need blood transfusion; 6. Failure to complete follow-up;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin level;Ferritin levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| AST, ALT levels;Cardiac function was evaluated by echocardiography (ejection fraction, end-diastolic volume, pulmonary artery systolic pressure, etc.);Incidence of pregnancy complications (preeclampsia, gestational diabetes mellitus, preterm birth, premature rupture of membranes, etc.);Fetal birth resolution (birth weight, APGAR score, NICU admission rate and duration, fetal hemoglobin level);Incidence of iron deficiency anemia in offspring at 6 months; | — |
Countries
China
Contacts
Public ContactLiao Jiujiang
Chongqing Health Center for Women and Children
Outcome results
None listed