Aortic Dissection
Conditions
Interventions
Case group:None
Control group:None
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria for the case group: 1) Age >= 18 years, regardless of sex; 2) Clearly diagnosed with aortic dissection (Stanford type A or B, acute or chronic) through imaging examinations (CT angiography (CTA), magnetic resonance imaging (MRI), or transesophageal echocardiography (TEE)); 3) The patient or their legal representative signs the informed consent form. Inclusion criteria for the control group: 1) Matched with patients in the case group in a 1:2 ratio based on age and sex; 2) Diagnosed with primary hypertension according to current hypertension guidelines; 3) The patient or their legal representative signs the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the case group: 1) Traumatic aortic dissection; 2) Iatrogenic aortic dissection; 3) Aortic dissection requiring emergency surgery; 4) Known diagnosis of inherited connective tissue diseases, such as Marfan syndrome, Loeys-Dietz syndrome, vascular Ehlers-Danlos syndrome, etc.; 5) Known secondary causes of hypertension, such as pheochromocytoma, Cushing's syndrome, etc.; 6) Severe renal insufficiency (eGFR < 30 ml/min/1.73m²), as it may affect aldosterone and renin levels; 7) Severe hepatic impairment (Child-Pugh class C); 8) Pregnant or lactating women; 9) Inability to cooperate with the study or provide complete medical history data. Exclusion criteria for the control group: 1) Any history of aortic diseases, including aortic dissection, aortic aneurysm, or aortic intramural hematoma; 2) History of severe cardiovascular diseases, such as recent (within 6 months) myocardial infarction, unstable angina, or severe heart failure (NYHA class IV); 3) Known secondary causes of hypertension, such as renovascular hypertension, pheochromocytoma, Cushing's syndrome, etc.; 4) Severe renal insufficiency (eGFR < 30 ml/min/1.73m²) or severe hepatic impairment; 5) Pregnant or lactating women; 6) Inability to cooperate with the study or provide complete medical history data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk Measure for Aldosterone Levels and Aortic Dissection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stratified Analysis and Adjustment for Risk Factors, Including Sex, Age, BMI, Smoking, and Medical History;To compare aldosterone levels before and after surgery; | — |
Countries
China
Contacts
Public ContactHe Yangyan
The First Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed