Inflammatory bowel disease
Conditions
Interventions
Guselkumab-treating Crohn's disease group:None
Guselkumab-treating ulcerative colitis group:None
Healthy control group:None
Sponsors
The Sixth Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Eligible participants were adults aged 18-60 who had voluntarily provided informed consent, with a diagnosis of CD or UC confirmed per the "Consensus on the Diagnosis and Management of Inflammatory Bowel Disease (2018, Beijing)," and were currently on guselkumab therapy. The selection criteria for the healthy volunteer group are voluntary signing of informed consent forms, adults aged 18-60, and healthy volunteers.
Exclusion criteria
Exclusion criteria: Exclusion criteria include subjects who meet any of the following conditions: unwillingness or inability to provide screening biopsies, blood, or stool samples; pregnancy; known bleeding disorder; diagnosis of IBD unclassified (IBD-U); presence of malignancy; acute gastrointestinal infection; diagnosis of colitis of unknown etiology; or diagnosis of an autoimmune disease (e.g., rheumatoid arthritis, systemic lupus erythematosus).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response rate;Clinical remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endoscopic response rate;Endoscopic remission rate; | — |
Countries
China
Contacts
Public ContactHongsheng Yang
The Sixth Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed