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Exploring the Protective Mechanism of Irisin in Acute Lung Injury by Inhibiting Pyroptosis of Lung Epithelial Cells via PPAR?/mTOR-Signaling-Mediated Autophagy

Exploring the Protective Mechanism of Irisin in Acute Lung Injury by Inhibiting Pyroptosis of Lung Epithelial Cells via PPAR?/mTOR-Signaling-Mediated Autophagy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113591
Enrollment
Unknown
Registered
2025-12-01
Start date
2026-01-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia

Interventions

Normal group:None

Sponsors

Zhejiang Provincial Tongde Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 14 Years

Inclusion criteria

Inclusion criteria: 1. Children aged 0 to 14 years; 2. Inclusion criteria for the control group children: Healthy children; 3. Inclusion criteria for children with pneumonia: Based on the diagnostic criteria in the 10th edition of the People's Medical Publishing House's "Pediatrics", they generally have symptoms of fever, cough, and expectoration, and lung auscultation reveals moderate to fine moist rales and/or chest imaging shows changes indicative of pneumonia; 4. The research subjects and their guardians agreed to participate in this study and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Severe heart and lung failure patients; 2. Pediatric tuberculosis; 3. Individuals with underlying diseases or immune deficiencies; 4. Merge other system infections.

Design outcomes

Primary

MeasureTime frame
Leukocyte;Neutrophil;TNF-a;IL-1ß;Cysteine proteolytic enzyme-1,(Caspase-1);NOD-likereceptorprotein3(NLRP3);IFN-?;IL-6;IL-6;GasderminD;IL-18;IFN-?;ASC;TNF-a;

Countries

China

Contacts

Public ContactFengyun Wan

Zhejiang Provincial Tongde Hospital

928165292@qq.com+86 18852890341

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026