Dystonia
Conditions
Interventions
Clonazepam Group:None
Trihexyphenidyl Group:None
Baclofen Group :None
Retrospective cohort:None
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Children aged 1–18 years; 2.Meeting the diagnostic criteria for dystonia as defined in the 2013 consensus update "Phenomenology and Classification of Dystonia", with acquired etiology (e.g., encephalitis, traumatic brain injury); 3.No prior use of anti-dystonia medications or a washout period of >=3 months since the last dose; 4.Monotherapy for dystonia (single-agent treatment); 5.Informed consent obtained from legal guardians with signed consent forms.
Exclusion criteria
Exclusion criteria: 1.Genetic or idiopathic dystonia; 2.Comorbid epilepsy; 3.Severe spasticity (modified Ashworth scale >= Grade 2); 4.Contraindications to the study medications; 5.Combination therapy (>=2 anti-dystonia drugs).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Independence ;Dystonia Rating ;Functional Independence ;Functional Independence ;Dystonia Rating ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Medication Adherence;Adverse Drug Reactions (Fatigue, Nausea and vomiting);Pain ;Laboratory Monitoring;Complications; | — |
Countries
China
Contacts
Public ContactNong Xiao
Children's Hospital of Chongqing Medical University
Outcome results
None listed