Nephrotic Syndrome
Conditions
Interventions
Group A: Furosemide (standard dose) and metolazone (standard dose):Furosemide: Administered at a weight-based dose (e.g., 1-2 mg/kg/day), adjusted as necessary based on clinical response.
Metolazone:
Group B: Furosemide (standard dose) and spironolactone (standard dose):Furosemide: Administered at a weight-based dose (e.g., 1-2 mg/kg/day), adjusted as necessary based on clinical response.
Spironol
Sponsors
Khushnood Maqbool
Eligibility
Sex/Gender
All
Age
1 Years to 15 Years
Inclusion criteria
Inclusion criteria: 1. Children diagnosed with nephrotic syndrome with refractory edema or severe anasarca and not achieving weight loss or diuresis after 2 days of treatment with oral furosemide therapy. 2. Age > 1 year and less than 15 years.
Exclusion criteria
Exclusion criteria: 1. Patients taking albumin therapy. 2. Nephrotic syndrome patient caretakers who will refuse to give consent 3. The patients who will achieve weight loss or diuresis within 2 days of treatment with oral furosemide therapy. Children 15 years with nephrotic syndrome admitted in our department fulfilling inclusion criterion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum electrolytes;urine output and edema; | — |
Countries
Pakistan
Contacts
Public ContactKhushnood Maqbool
University of Child Health Sciences,The Children's Hospital, Lahore
Outcome results
None listed