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Exploration of the Efficacy of Different Electroacupuncture Stimulation Parameters for Generalized Anxiety Disorder and the Central Mechanisms Underlying the Anxiety-Relieving Effects

Exploration of the Efficacy of Different Electroacupuncture Stimulation Parameters for Generalized Anxiety Disorder and the Central Mechanisms Underlying the Anxiety-Relieving Effects

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500113568
Enrollment
Unknown
Registered
2025-12-01
Start date
2026-01-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized anxiety disorder

Interventions

control group:Acupuncture
2 Hz/100Hz EA group:Electroacupuncture
2 Hz EA group:Electroacupuncture
100Hz EA group:Electroacupuncture

Sponsors

The Second Affiliated Hospital of Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Meets the diagnostic criteria for GAD; 2.Age between 18 and 60 years; 3.Is conscious and able to engage in normal communication; 4.Demonstrates good compliance, is willing to participate in the study, and has signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Organic mental disorders, schizophrenia, bipolar disorder, mania or other mental illnesses, alcohol and drug addiction, current drug use disorder and lifetime drug abuse, after stroke, postpartum anxiety; 2. Those who have previously committed suicide or have a severe suicidal tendency; 3. Pregnant or lactating women; 4. Mental retardation, difficult to cooperate with doctors; 5. Those with bleeding tendency, coagulation dysfunction, implanted metal implants in the body, etc. who are contraindicated for electro-acupuncture; 6. Those who have participated in other clinical trials within the last month.

Design outcomes

Primary

MeasureTime frame
Hamilton Anxiety Rating Scale, HAMA;

Secondary

MeasureTime frame
Incidence of adverse events;Pittsburgh Sleep Quality Index, PSQI;The Short Form-12 Health Survey, SF-12;The Zung Self-Rating Anxiety Scale, SAS;

Countries

China

Contacts

Public ContactXiaoting Wu

The Second Affiliated Hospital of Zhejiang University School of Medicine

xiaotwu@163.com+86 558 3725528

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026