Perioperative neurocognitive disorders
Conditions
Interventions
none postoperative delirium group:None
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
65 Years to 95 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 65 to 95 years, inclusive.?? ??(2) Scheduled for joint arthroplasty under spinal anesthesia.?? ?(3) Ability to communicate simply with the investigators and complete the assessments of relevant scales.?? ??(4) Patients and their family members have provided informed consent to participate in this research study.
Exclusion criteria
Exclusion criteria: (1) Patients classified as ASA physical status IV or V.?? ??(2) History of pre-existing psychiatric or neurological disorders (e.g., intracranial tumors, Alzheimer's disease, etc.).?? ??(3) History of surgery within the past 12 months.?? ??(4) Long-term use of benzodiazepines or other antipsychotic medications.?? ??(5) Patient or family member declined to participate in the study.?
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium;postoperative cognitive dysfunction;Perioperative neurocognitive disorders;Functional magnetic resonance of the head; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalogram;insulin;insulin;MBP;NfL;sulfatide;MPZ;MAG;MOG; Amyloid ß;BDNF;noradrenaline;cortisol;Salivary a -amylase; | — |
Countries
China
Contacts
Public ContactJiang Guiping
The Third Xiangya Hospital of Central South University
Outcome results
None listed