Post-stroke cognitive impairment
Conditions
Interventions
iTBS BCI group:Each stimulation used a three-pulse 50 Hz series with a repetition period of 5 Hz, providing a total of 600 stimulation pulses. The stimulation intensity was 80% of the individual's act
iTBS sham stimulation BCI group:They received the same BCI training procedure as the experimental group, but the transcranial magnetic stimulation device did not output actual pulses (sham stimulation
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 50–75 years, right-handed; 2. First-time unilateral stroke confirmed by imaging (including infarction in the middle cerebral artery region), with stable condition and no progressive deterioration; 3. Educational level of junior high school or above, able to cooperate with cognitive assessment; 4. Montreal Cognitive Assessment (MoCA) total score <26 points, and visuospatial and executive function sub-item score <4 points (out of 5), confirming presence of executive function impairment; 5. Mild motor impairment, but able to walk at least 10 meters independently or with assistive devices, and capable of completing the Timed Up and Go Test (TUGT); 6. Able to understand and cooperate with near-infrared spectroscopy (fNIRS) and transcranial magnetic stimulation (TMS) procedures; 7. Voluntarily participating in the trial and has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with unstable acute stroke or those experiencing progressive or recurrent strokes; 2. Patients with a history of or current serious neurological diseases (such as cerebral hemorrhage, traumatic brain injury, Parkinson’s disease), severe medical conditions (severe cardiopulmonary, hepatic, or renal insufficiency, etc.), or severe mental illness; 3. Patients with sensory aphasia, severe cognitive impairment (such as dementia), or visual/auditory impairment that prevents them from cooperating with assessment and training; 4. Patients with a history of epileptic seizures or a family history of epilepsy (to be excluded due to the potential increased risk of epilepsy from TMS); 5. Patients whose recent MRI shows new cerebral infarction foci or large-area infarction formation; 6. Patients with malignant tumors and limited life prognosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Timed Up and Go Test (TUGT) time;Proportion of motor imagination;Brain activation;Functional connectivity;Brain network analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| KVIQ-20 motor imagery ability;IMI Intrinsic Motivation Scale;CES-D Depression scale;Sleep Assessment Scale; | — |
Countries
China
Contacts
Public ContactXu Guangqing
Department of Rehabilitation Medicine, Guangdong Provincial People's Hospital
Outcome results
None listed