Patients with fundus diseases (including early-stage diabetic retinopathy, early-stage age-related macular degeneration, central serous chorioretinopathy, and inherited retinal diseases)
Conditions
Interventions
Early diabetic retinopathy group:None
Normal control group:None
Early age-related macular degeneration group:None
Contral serous chorioretinopathy group:None
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with the following retinal diseases are eligible: including, but not limited to, retinal vascular diseases (e.g., diabetic retinopathy, retinal vein occlusion), macular diseases (e.g., dry age-related macular degeneration, central serous chorioretinopathy), inherited retinal disorders (e.g., retinitis pigmentosa, cone-rod dystrophy, occult macular dystrophy), and other fundus conditions. There are no restrictions regarding age or sex. Specifically, for diabetic retinopathy (DR), the study will primarily enroll patients with early-stage DR. This is defined according to the International Clinical Diabetic Retinopathy Disease Severity Scale as DR Stage I patients, i.e., those with early non-proliferative diabetic retinopathy (NPDR) presenting only with microaneurysms. 2.There are no restrictions regarding age or sex; 3.Patients voluntarily participate in the study and provide informed consent; 4.Good study compliance; 5.If both eyes meet the image quality standards, then both are included in the analysis. If only one eye meets the standards, then that eye alone is included.
Exclusion criteria
Exclusion criteria: 1.Subjects with an intraocular pressure (IOP) greater than 21 mmHg in either eye, or with any other condition that contraindicates pupillary dilation; 2.Aphakia; 3.Subjects with opacities of the refractive media that preclude the acquisition of satisfactory images; 4.Subjects with poor fixation or any other condition that precludes adequate cooperation during the examination; 5.Vulnerable populations, such as pregnant women, minors, and individuals with psychiatric disorders; 6.Deemed unsuitable for participation in the clinical study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cone Photoreceptors: cell density, cell spacing, spacing standard deviation, cell regularity Vascular Blood Flow: retinal vessel wall thickness, vascular lumen diameter, vascular diameter;Fundus autofluorescence;Central macular thickness;Vessel blood flow: retinal vessel wall thickness, lumen diameter, vessel diameter, wall-to-lumen ratio, blood flow velocity; | — |
Countries
China
Contacts
Public ContactSun Zuhua
Eye Hospital, Wenzhou Medical University
Outcome results
None listed