Postoperative delirium
Conditions
Interventions
Experimental group:Postoperative analgesia pump administered Oxycodone 1 mg/mL, background rate 0.5 mg/h, single PCA dose 1 mg, lockout time 10 minutes.
Control group:Postoperative analgesia pump administered sufentanil 2 µg/mL, background rate 2 µg/h, single PCA dose 2 µg, lockout time 10 minutes
Sponsors
Henan University Huaihe Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2. ASA classification II-III; 3. Voluntarily signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe cognitive impairment (MMSE <24) or dementia before surgery; 2. Severe hearing or vision impairment preventing communication; 3. Long-term use of opioids or psychiatric medications; 4. Allergy to the study drug; 5. Severe liver or kidney dysfunction (Child-Pugh Class C or eGFR <30 ml/min); 6. Contraindications to regional anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain intensity at rest and during activity;Total postoperative opioid consumption;Postoperative rehabilitation indicator: active knee flexion angle within 48 hours after surgery.;Cognitive Function Assessment;Overall patient satisfaction; | — |
Countries
China
Contacts
Public ContactXin Wenqi
Henan University Huaihe Hospital
Outcome results
None listed