Hypopharyngeal squamous cell carcinoma
Conditions
Interventions
Experimental group:Receive two courses of neoadjuvant therapy with PD-1 inhibitors combined with chemotherapy
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age >=18 years old; 2) The pathological diagnosis is hypopharyngeal squamous cell carcinoma.; 3) At the initial diagnosis, it was stage T3-4 hypopharyngeal squamous cell carcinoma (according to AJCC 8th Edition); 4) Agree to receive PD-1 inhibitor immunotherapy combined with chemotherapy as neoadjuvant therapy, followed by surgical treatment.
Exclusion criteria
Exclusion criteria: 1) Has undergone surgery, radiotherapy, chemotherapy, immunotherapy or targeted therapy in the past; 2) There is distant metastasis or recurrence; 3) Combined with other primary malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The pathological response rate of locally advanced hypopharyngeal carcinoma: including significant pathological response (MPR) and complete pathological response (pCR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Two-year lung survival rate (LFS);Two-year overall survival (OS) rate;Two-year progression-free survival (PFS) rate; | — |
Countries
China
Contacts
Public ContactCai Qian
Zhujiang Hospital of Southern Medical University
Outcome results
None listed