Osteoarthritis
Conditions
Interventions
Part One: Patients with Early and Mid-stage Knee Osteoarthritis:Collect clinical information and imaging information, etc.
The first group: Patients with advanced knee osteoarthritis:Collect clinical information and imaging information, etc.
Part One: Healthy Volunteers:Collect clinical information and imaging information, etc.
The second part: Patients with osteoarthritis of the knee joint:Collect clinical information and imaging information, etc.
Sponsors
Shengjing Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Part 1: Inclusion Criteria 1. Inclusion criteria for healthy volunteers: (1) No symptoms of knee pain or functional impairment; (2) Signed informed consent form; (3) No history of knee disease or surgery; (4) Age 18–90 years. 2. Inclusion criteria for KOA patients: (1) Clinically diagnosed with KOA (patients undergoing total knee arthroplasty at our hospital may provide pathological specimens); (2) Signed informed consent form; (3) No contraindications to MRI; (4) Age 18–90 years. Part 2: Inclusion Criteria 1. Clinically diagnosed with KOA; 2. Complete knee MRI and X-ray examinations available in the imaging system; 3. Age 18–90 years; 4. Complete clinical data, including age, physical examination, and laboratory test results.
Exclusion criteria
Exclusion criteria: 1. Part 1: Exclusion Criteria (1) Severe comorbidities (e.g., liver or renal failure); (2) Secondary arthritis due to inflammation; (3) MRI contraindications (e.g., cardiac stents, metallic implants within the body, severe claustrophobia); (4) Inability to cooperate with questionnaire completion. 2. Part 2: Exclusion Criteria (1) Severe comorbidities (e.g., liver or renal failure); (2) Secondary arthritis due to inflammation; (3) MRI contraindications (e.g., cardiac stents, metallic implants within the body, severe claustrophobia); (4) Incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Imaging data collection (conventional MRI, UTE sequence MR scan, and full-length standing X-ray examination of both lower limbs);Basic clinical information and survey questionnaire information;Histopathological indicators of cartilage and muscle tissue;Various indicators of blood composition;Assessment of sarcopenia; | — |
Countries
China
Contacts
Public ContactPan Shinong
Shengjing Hospital of China Medical University
Outcome results
None listed