melasma
Conditions
Interventions
Group A:picosecond laser, 3 treatments every 4 weeks for a total of 8 weeks. Parameters: Focus, DLA handset, spot 10mm, energy 0.21J/cm^2, frequency 10Hz, scan the lesion area 3-5 times, and the skin
Group B:Picosecond Laser Combined with Recombinant Humanized Collagen
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18-60 years; 2. Patients diagnosed with melasma and symmetrical distribution of the face, the course of the disease is at least 6 months; 3. The facial skin is basically intact, with no obvious inflammation, ulceration, exudation, etc.; 4. Those who have not received treatment (including laser and oral topical drugs) in the past 6 months; 5. Those who have no history of exposure to the sun in the past 3 months; Have good adherence and be able to participate in regular follow-up visits.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiovascular and cerebrovascular, liver and kidney and hematopoietic system and other systemic diseases, mental diseases, and immunodeficiency diseases; 2. Pregnant or lactating women; Those who are allergic to the test drug and its components; Females of childbearing potential on oral contraceptives and hormone replacement therapy; 3. Investigators who are participating in other clinical trials; 4. Those who, in the opinion of the investigator, are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melasma area severity index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physician’s overall assessment;Patient’s overall assessment; | — |
Countries
China
Contacts
Public ContactFenglin Zhuo
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed