Intubation response
Conditions
Interventions
Middle-aged group:Intravenous injection: Sufentanil 0.3µg /kg, esketamine 0.3mg/kg.
The disodium phosphopropofol was experimentally analyzed using the Dixon sequential method: Slowly administer disodi
Sponsors
Affiliated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age: 45 to 85 years old, gender not limited; 2. Patients who are scheduled for elective surgery under general anesthesia and single-lumen tracheal intubation; 3. The ASA score is Grade I or Grade II; 4.18 kg/m^2< BMI < 28kg/m^2; 5. Clearly understand and voluntarily participate in this research, and sign the informed consent form by oneself.
Exclusion criteria
Exclusion criteria: Patients who have not received regular antihypertensive treatment or have poor blood pressure control (systolic blood pressure >=160 mmHg or =100 mmHg); 2. Heart rate (HR) 100 beats per minute; 3. Uncontrolled diabetes and coronary heart disease; 4. Severe liver and kidney dysfunction (Child-Pugh score > 7, eGFR < 30 ml/min/1.73m^2); 5. Difficult airway; 6. Allergic diseases or allergies to the investigational drugs; 7. Family history of malignant high fever; 8. Patients with untreated or uncontrolled hyperthyroidism; 9. Has participated in other drug clinical trials as a subject within the past three months; 10. Pregnant or breastfeeding, or planning to become pregnant within one month after surgery; 11. History of alcohol abuse or drug abuse;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubation reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Record the MAP and HR of the patients before the start of anesthesia induction (T1) and 1 minute after the disappearance of eyelash reflex (T2). The maximum values of MAP and HR within 3 minutes after intubation (T3);The period from the start of anesthesia to the loss of consciousness of the subject (MOAA/S score <=1) and BIS<=60;Did the patient complain of skin itching and discomfort throughout the injection process;Dosage of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactLi Rui
Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed