Sepsis
Conditions
Interventions
Healthy alcohol consumption group:None
Healthy control group:None
ICU non-infected control group:None
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.ICU Sepsis Group: Obtain informed consent from the subjects or their legal representatives; Age >=18 Meet the diagnostic criteria of sepsis3.0; 2.ICU non-infection control group: Obtain informed consent from the subjects or their legal representatives; Age >=18 There is no suspected or confirmed infection. 3. Healthy control group: Obtained the informed consent of the subjects themselves; Age >=18 There are no known acute or chronic diseases at present. No habit of drinking alcohol; 4. Healthy drinking group: Obtained the informed consent of the subjects themselves; Age >=18 There are no known acute or chronic diseases at present. There should be a history of regular alcohol consumption, with a single alcohol intake of no less than 70g for men and no less than 56g for women. Regular alcohol consumption should be three or more times a week, and the drinking habit should be stable for three months or more.
Exclusion criteria
Exclusion criteria: 1.ICU Sepsis group: Age >=90; Has a long history of oral antibiotics; Participate in other interventional research; Pregnant or lactating women; The researcher judged that it was not suitable to participate in this study. 2.ICU non-infection control group: Age >=90; Has a long history of oral antibiotics; Participate in other interventional research; Pregnant or lactating women; Infection occurs within 48 hours after enrollment; The researcher judged that it was not suitable to participate in this study. 3. Healthy control group: Age >=90 Has a long history of oral antibiotics and has taken any prescription drugs within two weeks; Participate in other interventional research; Pregnant or lactating women; There is a history of major illness or surgery within four weeks; The researcher judged that it was not suitable to participate in this study. 4. Healthy drinking group: Age >=90; Has a long history of oral antibiotics and has taken any prescription drugs within two weeks; Participate in other interventional research; Pregnant or lactating women; There is a history of major illness or surgery within four weeks; The researcher judged that it was not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota and metabolites and SOFA score;The correlation of the 28-day mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiota/metabolite characteristics and hospital stay;The relationship between organ failure; | — |
Countries
China
Contacts
Public ContactZhenhua Zeng
Southern Medical University Southern Hospital
Outcome results
None listed