Overweight, Prediabetes
Conditions
Interventions
Overweight adults with pre-diabetes group:60 minutes of moderate-intensity cycling on a stationary ergometer. The exercise intensity will be targeted at 40–59% of their heart rate reserve (HRR).
Overweight adults without pre-diabetes group:60 minutes of moderate-intensity cycling on a stationary ergometer. The exercise intensity will be targeted at 40–59% of their heart rate reserve (HRR).
Sponsors
Hong Kong Baptist University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged 18–65 years; 2.Overweight (BMI >=23 kg/m^2, Asian-specific criteria); 3. Prediabetes group: HbA1c levels between 5.7%–6.4% (39–47 mmol/mol) or fasting glucose between 5.6–6.9 mmol/L (100–125 mg/dL); 4.Control group: HbA1c levels <5.7% (<39 mmol/mol) and fasting glucose <5.6 mmol/L (<100 mg/dL).
Exclusion criteria
Exclusion criteria: 1. Diagnosis of diabetes (Type 1, Type 2, or gestational diabetes); 2. Hormonal imbalances or metabolic disorders (e.g., PCOS, thyroid dysfunction); 3. History of cardiovascular disease or uncontrolled hypertension (blood pressure >140/80 mmHg); 4. Use of medications/ supplements affecting lipid or glucose metabolism; 5. Pregnancy, breastfeeding, or planning pregnancy during the study; 6. Contraindications for MRI/MRS (e.g., metallic implants, severe claustrophobia);; 7. Clinical evidence or history of severe hepatic disease, advanced cirrhosis, or non-alcoholic steatohepatitis (NASH), as screened via baseline structural abdominal MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intramyocellular Lipid; | — |
Countries
China
Contacts
Public ContactTAM, Tsz King, Bjorn
Hong Kong Baptist University
Outcome results
None listed