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The mechanism of high homocysteine regulating thioredoxin activating oxidative stress through histone modification in children with hypertension

The mechanism of high homocysteine regulating thioredoxin activating oxidative stress through histone modification in children with hypertension

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113490
Enrollment
Unknown
Registered
2025-11-28
Start date
2025-11-30
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension in children

Interventions

H-type hypertension group:None
Control group:None

Sponsors

Capital Center for Children’s Health, Capital Medical University, Capital Institute of Pediatrics
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 17 Years

Inclusion criteria

Inclusion criteria: 1. H-type hypertension group: hospitalized 6-17 years old patients with newly diagnosed essential hypertension without treatment, elevated Hcy and no other serious diseases, and their parents/guardians signed the informed consent. 2. Simple hypertension group: hospitalized 6-17 years old patients with newly diagnosed essential hypertension without treatment, normal Hcy and no other serious diseases, and their parents/guardians signed the informed consent. 3. Control group: healthy children underwent physical examination, and their parents/guardians signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. H-type hypertension group, Simple hypertension group: (1) secondary hypertension; (2) complicated with serious cardiovascular disease, liver and kidney function, malignant tumor and endocrine abnormalities; (3) recent use of folic acid or vitamin B12; (4) patients who had taken antihypertensive drugs; (5) reexamination patients; (6) the patient participated in other clinical studies. 2. Control group: special lifestyle or environmental factors that may affect blood pressure, such as chronic mental stress.

Design outcomes

Primary

MeasureTime frame
Homocysteine;S-adenosylmethionine;Folic acid;Vitamin B6;Vitamin B12;

Countries

China

Contacts

Public ContactQin Zhang

Capital Center for Children’s Health, Capital Medical University, Capital Institute of Pediatrics

zhangqin87@pumc.edu.cn+86 156 5262 7876

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026