Knee pain
Conditions
Interventions
intervention gruop1:The adductor canal block was performed using a mixture of 2 µg/kg hydromorphone (2 mL) and 0.25% ropivacaine (18 mL)
control gruop:0.25% ropivacaine 20ml for adductor canal block
intervention gruop2:The adductor canal block was performed using a mixture of 4 µg/kg hydromorphone (2 mL) and 0.25% ropivacaine (18 mL)
intervention gruop3:The adductor canal block was performed using a mixture of 6 µg/kg hydromorphone (2 mL) and 0.25% ropivacaine (18 mL)
intervention gruop4:The adductor canal block was performed using a mixture of 8 µg/kg hydromorphone (2 mL) and 0.25% ropivacaine (18 mL)
intervention gruop5:The adductor canal block was performed using a mixture of 10 µg/kg hydromorphone (2 mL) and 0.25% ropivacaine (18 mL)
Sponsors
The Second affiliated Hospital of Zhejiang Chinese Medicine University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2018 edition); 2. Age 50 ~ 80 years old; 3. American Society of Anesthesiologists (ASA) grade I to III; 4. body mass index (BMI) 18-25 kg/m^2; 5. No moderate or severe cardiopulmonary insufficiency; 6. No severe hypertension, diabetes, no history of major surgery or mental illness; 7. Patient signs informed consent.
Exclusion criteria
Exclusion criteria: 1. Chronic opioid users (continuous use for =4 weeks, e.g., morphine, fentanyl, etc.); 2. History of ropivacaine allergy; 3. Chronic alcohol abuse or alcohol dependence; 4. Patients with hepatic or renal insufficiency; 5. Individuals with poor cardiopulmonary function; 6. Previous vascular surgery on the affected lower limb; 7. Non-ambulatory patients (wheelchair-bound long-term); 8. Infection at the puncture site; 9. Uncooperative or non-communicative patients; 10. Patients with immune system disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score after total knee replacement;Quadriceps muscle strength score after total knee replacement;Number of PCIA compressions after total knee replacement;Ramasy sedation score after total knee replacement;BCS comfort score after total knee replacement;Use of supplemental remedial analgesics;Postoperative 24-hour serum IL-6 levels;Postoperative 24-hour serum IL-10 levels;Postoperative 24-hour serum PGE2 levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactLi Yuebing
The Second affiliated Hospital of Zhejiang Chinese Medicine University
Outcome results
None listed