oral proliferative verrucous leukoplakia
Conditions
Interventions
Treatment group:Topical bleomycin treatment
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age of 18 to 85 years old; 2.All participants should be diagnosed of oral proliferative verrucous leukoplakia, with hyperplasia or epithelial dysplasia, and rule out cancer. 3.Free of topical treatment for the oral lesions within one month; 4.All participants volunteered to participate with informed consents.
Exclusion criteria
Exclusion criteria: 1.Severe abnormal liver and kidney function; 2.People with lung infection or pulmonary insufficiency; 3.Pregnant or lactating women; 4.Those who are known to have a history of allergy to the test drug, cannot tolerate it, or are allergy susceptibility; 5.Those with mental disorders who cannot cooperate well and cannot evaluate changes regularly; 6.Those with malignancies or other serious systemic diseases being treated; 7.Those with difficulty cooperating or unwillingness to participate in the trial; 8.Those who participated in other clinical trials within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesion area; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale Score;Cytology results of exfoliated cells and DNA aneuploidy status;Cancerous changes; | — |
Countries
China
Contacts
Public ContactHu Xiaosheng
Peking University Hospital of Stomatology
Outcome results
None listed