Rectal cancer
Conditions
Interventions
Full neoadjuvant therapy in the observation group of low - and medium-risk low rectal cancer:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18 -80 years old; Gender is not limited. 2. Rectal adenocarcinoma confirmed by pathology, and immunohistochemical and/or genetic testing as pMMR/MSS; 3. The tumor evaluated by thoracoabdominal CT, rectal color Doppler ultrasound and MRI has the following characteristics: The distance from the lower edge of the tumor to the anal edge measured by digital rectal examination or MRI is 1mm), EMVI (+/-); The lateral lymph nodes are negative and less than 7mm. The long diameter of the tumor is less than or equal to 5cm. The tumor circumference is less than or equal to 2/3. 4. MRI assessment was effective after two or more cycles of XELOX regimen induction chemotherapy (tumor long diameter) A reduction of =30% compared to before treatment. 5. Subsequently complete TNT treatment (including long-term chemoradiotherapy and consolidation chemotherapy, with 25 to 28 sessions of radiotherapy and 6 to 8 cycles of chemotherapy). 6. (Prospective Part) Sign the informed consent form for this observational study.
Exclusion criteria
Exclusion criteria: 1.History of or concurrent other malignancies (except for cured basal cell carcinoma of the skin or carcinoma in situ of the cervix); 2.Incomplete clinical data precluding effective evaluation; 3.(For the prospective cohort) Refusal to provide written informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Organ preservation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical complete response;Local recurrence rate;Metastasis-free survival rate;Local regrowth rate;Overall survival rate;pCR rate; | — |
Countries
China
Contacts
Public ContactZiqiang Wang
West China Hospital of Sichuan University
Outcome results
None listed