Hemodynamic fluctuations and the incidence of adverse reactions were observed in ASA class 1-2 patients administered two different groups of anesthetics.
Conditions
Interventions
Experimental group:Nalbuphine-Ciprofol
Control group:Nalbuphine-Propofol
Sponsors
The Fourth People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients meeting the following criteria were included: indications for painless gastrointestinal endoscopy with good tolerance, ASA physical status ?-?, aged 18-65 years (regardless of gender), body mass index 18 kg/m² <= BMI <30 kg/m², and normal hepatic and renal function.
Exclusion criteria
Exclusion criteria: 1. Have a history of allergic reaction to anesthetic drugs or abnormal recovery after anesthesia; 2. Have hypertension, diabetes, hyperlipidemia, or other severe organ dysfunction; 3. Have bradycardia, with a heart rate of less than 50 beats per minute; 4. Have a history of chronic pain and have been taking opioid drugs for a long time; 5. Have functional disorders such as language, hearing, and mental functions; 6. The examination time is more than 30 minutes; 7. Patients considered unsuitable for clinical research by the researchers include those who have had acute respiratory inflammation within 2 weeks and have a history of not recovering, patients with snoring, sleep apnea syndrome, or long-term heavy alcohol consumption.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| injection pain;The incidence of hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;bradycardia;respiratory depression;allergy;Physical movement;Narcotrend: Level of Anesthesia Depth and Grade;pharyngeal reflex;bucking;anesthesia duration;muscle twitching;Anesthetic dosage;Blood pressure(SBP DBP MAP);hiccups; | — |
Countries
China
Contacts
Public ContactHu Xiaoli
The Fourth People's Hospital of Shenzhen
Outcome results
None listed