Persistent High-Risk Human Papillomavirus (HR-HPV) Infection
Conditions
Interventions
There are four types of population: persistent cervical HR-HPV infection (SPI), persistent cervical HR-HPV infection (LSIL), persistent cervical HR-HPV infection (HSIL), and invasive cervical cancer.:
Cervical polyp patients:None
Sponsors
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
21 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Female patients aged 21-75 years with sexual activity history; (2) Meeting the diagnostic criteria for cervical HR-HPV infection or having a diagnosis of cervical polyp with concurrent negative results for both cervical TCT and HPV tests; (3) Intact cognitive and language function, with the ability to provide a clear self-assessment of symptoms; (4) Willingness to provide written informed consent and to comply with all study procedures, including clinical interviews, questionnaire completion, and macro- and micro-level examinations.
Exclusion criteria
Exclusion criteria: (1) Congenital absence of vagina or other reproductive tract malformations; (2) Individuals with various autoimmune diseases, sexually transmitted infections (including HIV/AIDS and syphilis), or those with compromised immune function due to immunosuppressive therapy; (3) Patients with severe primary diseases of the liver, spleen, lungs, kidneys, cardiovascular or hematopoietic systems, or malignant tumors, where these conditions may introduce significant confounding factors in constitutional assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colposcopy images;Tongue diagnosis involves the collection of tongue images;Clinical Information Collection in Traditional Chinese Medicine through Four Diagnostic Methods.;Transcriptomics of Cervical Lesion Tissues;The pulse diagnostic device acquires pulse diagrams and pulse patterns.;Identification of Constitution Types in Traditional Chinese Medicine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Infrared Thermographic Imaging Technology;Human Weak Magnetic Field Sensing and Evaluation Device;Vaginal Secretion Metabolomics;Microbiome analysis of vaginal secretions; | — |
Countries
China
Contacts
Public ContactXiao Jing
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed