Weak bladder
Conditions
Interventions
Probiotic group:Oral probiotic powder, once a day, 1 bag each time (each bag contains =109 CFU of active probiotics)
Placebo group:Oral placebo, 1 bag per day (maltodextrin)
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. 40 years old to 80 years old. 2. Gender: Unrestricted. 3. No antibiotic treatment within the past month. 4. No anti-inflammatory treatment within the past month. 5. Clinical diagnosis of weak bladder. 6. Subjects are willing to maintain normal eating and exercise habits to avoid significant weight changes during the study period and are able to understand the nature of the study. 7. Able to sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Subjects with severe chronic diseases (including heart failure, renal failure, lung disease, rheumatism, stroke, chronic cancer, or blood diseases, etc.) 2. Subjects with severe cardiovascular and cerebrovascular diseases and related surgical history 3. Subjects requiring long-term antibacterial or antiviral treatment 4. Subjects who have undergone cholecystectomy, intestinal resection, or gastrectomy 5. Acute inflammation 6. End-stage renal failure 7. Abnormal heart rhythm (lower or higher than 60-100 bpm) 8. Subjects allergic to maltodextrin or other drugs 9. Malignant tumors 10. Subjects who participated in another study within one month before the start of the study 11. Subjects who received medications that may affect the urinary system or took prebiotic or probiotic dietary supplements 12. Subjects who have lost more than 10% of their weight in the past 6 months or are currently dieting Pregnant women 13. Subjects allergic to medications 14. Subjects deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postvoid residual urine volume;Body mass index (BMI);Serum inflammatory factor levels;Serum metabolome ;3*24-hour urination frequency;3*24-hour dietary ;Fecal and urine microbiome ; | — |
Countries
China
Contacts
Public ContactMa Xin
Affiliated Hospital of Jiangnan University
Outcome results
None listed