Ischemic stroke
Conditions
Interventions
Tirofiban group:Patients will receive intravenous tirofiban before endovascular treatment(0.4 µg/kg/min, intravenous infusion within 30 minutes, and 0.1 µg/kg/min intravenous infusion for 23.5 hours).
Placebo group:Patients will receive intravenous placebo before endovascular treatment(0.4 µg/kg/min, intravenous infusion within 30 minutes, and 0.1 µg/kg/min intravenous infusion for 23.5 hours).
Sponsors
General Hospital of Northern Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Time from onset to randomization between 4.5 and 12.0 hours; 3. Preliminary diagnosis of anterior circulation ischemic stroke based on clinical symptoms or imaging; 4. National Institutes of Health Stroke Scale (NIHSS) score = 6; 6. Computed Tomography Angiography (CTA) / Magnetic Resonance Angiography (MRA) / Digital Subtraction Angiography (DSA) confirms occlusion of the intracranial segment of the internal carotid artery and the M1/M2 segments of the middle cerebral artery, and endovascular treatment is decided; 7. The patient or their family signs a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Age >= 18 years old; 2. Time from onset to randomization between 4.5 and 12.0 hours; 3. Preliminary diagnosis of anterior circulation ischemic stroke based on clinical symptoms or imaging examination; 4. National Institutes of Health Stroke Scale (NIHSS) score = 6 points; 6. Intracranial aneurysms or malformations, arterial tortuosity obstructing thrombectomy, space-occupying brain tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of mRS 0-2 at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day mRS score 0-1 or recovery to pre-stroke mRS score (%);Distribution of 90-day mRS scores;the proportions of patients with substantial reperfusion at initial preprocedure catheter angiogram ;DSA vascular recanalization success rate before the end of endovascular treatment;Postoperative 24h CTA/MRA vessel recanalization success rate;Change in NIHSS score 24 hours post-surgery;Changes in NIHSS scores 10 days after surgery;Occurrence of cardiovascular and cerebrovascular events within 90 days after surgery; | — |
Countries
China
Contacts
Public ContactChen Huisheng
General Hospital of Northern Theater Command
Outcome results
None listed