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Development of a Multimodal Syndrome Element Model and Mechanistic Research Based on the Gut-Muscle Axis in Cancer-Related Sarcopenia: Integration of a Knowledge Graph

Development of a Multimodal Syndrome Element Model and Mechanistic Research Based on the Gut-Muscle Axis in Cancer-Related Sarcopenia: Integration of a Knowledge Graph

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113386
Enrollment
Unknown
Registered
2025-11-27
Start date
2026-01-01
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer,Cancer-Related Sarcopenia

Interventions

Liver-Kidney Deficiency Group:N/A
Balanced Constitution Group:N/A

Sponsors

Zhejiang Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age > 18; 2.Meeting the diagnostic criteria for gastric cancer, liver cancer, colorectal cancer, or esophageal cancer (according to the Chinese Society of Clinical Oncology (CSCO) Guidelines for Cancer Diagnosis and Treatment). 3.Meets the diagnostic criteria for sarcopenia as defined by the Chinese Guidelines for the Diagnosis and Treatment of Sarcopenia (2024 Edition): when measured using multi-frequency bioelectrical impedance analysis (BIA), SMI 50. 7.No use of antibiotics within the past month. 8.The participant voluntarily agrees to join the study, is able to understand its requirements, provides signed informed consent, and demonstrates good compliance.

Exclusion criteria

Exclusion criteria: 1.Patients with concomitant severe heart disease, diabetes, hyperlipidemia, electrolyte disturbances, or abnormal hepatic/renal function; or those deemed ineligible by the investigator. 2.History of stroke or epilepsy; patients with primary brain tumors or brain metastases; inability to communicate verbally. 3.Patients deemed by the investigator to have uncontrolled comorbid severe cardiovascular/cerebrovascular diseases or other underlying medical conditions. 4.Diagnosis of dementia or a psychiatric disorder that results in the inability to express one's will appropriately. 5.Pregnant or lactating women, and pediatric patients. 6.Active infectious diseases caused by bacteria, fungi, viruses, mycoplasma, chlamydia, etc. 7.Subjects with critically incomplete general data or TCM four-examination information. 8.Any other circumstances in which the investigator deems the subject unable to complete or comply with the study requirements.

Design outcomes

Primary

MeasureTime frame
Changes in muscle mass;

Countries

China

Contacts

Public ContactLu Yi

Zhejiang Cancer Hospital

Luyi@zjcc.org.cn+86 571 88122222

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026