Triple-negative breast cancer
Conditions
Interventions
Control Arm:Standard Surgical Therapy
FUAS Intervention Arm:Focused Ultrasound Ablation Surgery
Sponsors
Lishui Central Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Patients with pathologically confirmed TNBC, with a pre-neoadjuvant therapy tumor stage of cT1-3N1-2M0; 2.Completion of a standard regimen of neoadjuvant therapy. 3.Confirmed non-pCR status assessed by MRI, ultrasound evaluation, and needle biopsy; 4.Single residual tumor diameter < 5 cm. 5.Good function of vital organs. 6.Residual tumor lesion is visible on ultrasound, with clear boundaries, located at least 1.0 cm from the skin or chest wall, and at least 2 cm from the nipple.
Exclusion criteria
Exclusion criteria: 1.Presence of detected metastases in bone, lung, brain, or other sites. 2.Coagulation dysfunction, myocardial diseases, uncontrolled diabetes mellitus, or other complex comorbidities. 3.Allergy to MRI contrast agents or ultrasound microbubble contrast agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pCR: pTis/0N0; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative adverse reactions of FUS ablation; | — |
Countries
China
Contacts
Public ContactCai Shibin
Lishui Central Hospital
Outcome results
None listed