Aortic Diseases
Conditions
Interventions
Observation group with spinal cord injury:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Diagnosed with acute Stanford A-type aortic dissection and undergoing emergency surgery; 3. Postoperative new-onset spinal cord injury (loss of motor/sensory function, ASIA grade A-D); 4. Imaging examinations (MRI/CTA) confirmed spinal cord ischemia or peripheral vascular involvement; 5. Those who have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. There was already neurological function impairment before the operation (such as spinal cord injury, sequelae of stroke); 2. Spinal cord injury is caused by non-ischemic factors (such as trauma, tumor compression, infectious myelitis, etc.); 3. Direct injury to the spinal cord during the operation; 4. Severe organ dysfunction (liver and kidney failure, cardiogenic shock, etc.); 5. Expected survival period < 30 days (such as advanced tumors, end-stage diseases, etc.); 6. Those with incomplete information; 7. Women during menstruation and pregnancy; 8. Those who have not signed the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative spinal cord injury;Hemodynamic changes in the aortic circulation;Preoperative and Postoperative CT of aortic dissection;Plasma metabolite; | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day postoperative mortality rate; | — |
Countries
China
Contacts
Public ContactJia Hu
Department of Cardiovascular Surgery, West China Hospital, Sichuan University
Outcome results
None listed