Resistant Tourette Syndrome
Conditions
Interventions
Single-group :Transcranial Magnetic Stimulation, TMS
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
8 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 8 and 18 years. 2. Diagnosed with Tourette's Syndrome according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). 3. Full-Scale Intelligence Quotient (FSIQ) >= 80 as assessed by the Wechsler Intelligence Scale. 4. A total score (motor tic score plus phonic tic score) of >= 50 on the Yale Global Tic Severity Scale (YGTSS). 5. Documented treatment resistance, defined as an inadequate response to comprehensive treatment (including standard behavioral interventions and pharmacotherapy) for a duration of at least one year. 6. Minimal comorbidities and absence of psychotic symptoms. 7. Willingness to receive TMS therapy, with both the participant and their legal guardian providing informed consent to adhere to the study's treatment and observation protocols. 8. For participants who, in the specialist's judgment, are unable to remain still for MRI scanning due to severe tics, both the participant and guardian consent to undergo MRI under sedation.
Exclusion criteria
Exclusion criteria: 1. Diagnosis of a learning disability (e.g., intellectual disability, global developmental delay, language delay) or any contraindication to the use of chloral hydrate. 2. Failure to meet any of the predefined inclusion criteria. 3. Presence of serious comorbid systemic diseases affecting the cardiovascular, hepatic, renal, hematopoietic, or nervous systems (e.g., chronic nephritis, hepatitis, congenital heart disease, Sydenham's chorea, subacute sclerosing panencephalitis). 4. Comorbid psychiatric disorders including conduct disorder, pervasive developmental disorder, intellectual disability, mood disorders, or schizophrenia. 5. Inability to complete the entire treatment course or having incomplete data that would impede the accurate assessment of efficacy or safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| YGTSS (Yale Global Tic Severity Scale);PUTS (Premonitory Urge for Tics Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| MRI metrics; | — |
Countries
China
Contacts
Public ContactZang Yufeng
The Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed