prolonged disorders of consciousness
Conditions
Interventions
Control group:Routine rehabilitation
Low intensity intervention group :Low intensity transcutaneous auricular vagus nerve stimulation
Moderate intensity intervention group :Moderate intensity transcutaneous auricular vagus nerve stimulation
High Intensity Intervention Group :High Intensity transcutaneous auricular vagus nerve stimulation
Sponsors
Zhangzhou Affiliated Hospital of Fujian medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65 years; 2. Patients with brain injury of known aetiology; 3. Diagnosed with vegetative state/minimally conscious state (based on CRS-R assessment over five consecutive days); 4. Disease duration exceeding 28 days; 5. Skin at the stimulation site intact and free from lesions; 6. Informed consent obtained.
Exclusion criteria
Exclusion criteria: 1. Patients with unstable vital signs; 2. Patients with active intracranial hypertension; 3. Patients with implanted cardiac pacemakers, cochlear implants, or intracranial metallic implants; 4. Patients with a history of central nervous system disorders; 5. Patients undergoing deep sedation due to general anaesthesia or central nervous system depressants; 6. Patients with bradycardia, atrial fibrillation, or atrioventricular block; 7. Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revised;functional connectivity strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glasgow Coma Scale;Glasgow Outcome Scale; | — |
Countries
China
Contacts
Public ContactHaoqing Jiang
Zhangzhou Hospital Affiliated to Fujian Medical University
Outcome results
None listed