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The effect of glycopyrrolate on postoperative nausea and vomiting in patients undergoing gynecological day surgery under general anesthesia with remimazolam

The effect of glycopyrrolate on postoperative nausea and vomiting in patients undergoing gynecological day surgery under general anesthesia with remimazolam

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500113357
Enrollment
Unknown
Registered
2025-11-27
Start date
2025-11-30
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting

Interventions

Glycopyrrolate group:Intravenous glycopyrrolate
Droperidol group:Intravenous droperidol

Sponsors

Weifang People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18–65 years, ASA grade I–III; 2. Body mass index 18–28 kg/m^2; 3. Patients scheduled to undergo gynecological day surgery.

Exclusion criteria

Exclusion criteria: 1. History of glaucoma or intraocular pressure > 21 mmHg; 2. Hypersensitivity to anticholinergic drugs, and/or known allergy to penehyclidine hydrochloride or any of its excipients; 3. Pre-existing acute or chronic nausea or vomiting, or gastrointestinal motility disorders; 4. Mental or cognitive impairment; 5. Hepatic or renal dysfunction.

Design outcomes

Primary

MeasureTime frame
Incidence of PONV within 24 hours after surgery;—

Secondary

MeasureTime frame
Incidence of PONV in PACU;Severity of PONV ;Adverse reactions during anesthesia ;Time to fall asleep;Time of resuscitation; Adverse reactions within PACU;—

Countries

China

Contacts

Public ContactJi Fanceng

Weifang People's Hospital

jifanceng@163.com+86 135 6369 8838

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026