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Analysis of the safety and effectiveness of low central venous pressure combined with ultrasound-guided thoracic paravertebral block technology in laparoscopic anatomical liver resection

Analysis of the safety and effectiveness of low central venous pressure combined with ultrasound-guided thoracic paravertebral block technology in laparoscopic anatomical liver resection

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500113355
Enrollment
Unknown
Registered
2025-11-27
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Focal liver lesions

Interventions

TPVB group:Paravertebral injection of 20 ml of 0.35% ropivacaine under ultrasound guidance
control group:For the sham injection of TPVB, the skin at the puncture site was also disinfected according to the standard, the gap was determined by the body surface marking method, normal saline was

Sponsors

Fuzhou University Affiliated Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 18 Years

Inclusion criteria

Inclusion criteria: (1) Be at least 18 years old and be able to give informed consent (provide relevant explanations if necessary). (2) Patients who underwent laparoscopic anatomical left hemihepatectomy under general anesthesia, aged 20 to 65 years old; (3) The expected operation time is >=2 hours (from skin incision to the end of wound suturing), and the expected hospitalization time is >=24 hours (from midnight on the day of operation) ; (4) No history of ropivacaine allergy.

Exclusion criteria

Exclusion criteria: 1. Allergic to the study drug; 2. Due to anatomical reasons, block operation cannot be performed; 3. Invasive mechanical ventilation is expected after surgery; 4. American Society of Anesthesiologists (ASA) >Grade IV; 5. Coagulation dysfunction (ie, INR>1.3 and/or platelet count <100×10^9/L); 6. Cognitive or language impairment, unable to participate in the research process and complete the questionnaire; 7. Failure to stop drugs that affect coagulation properly and promptly before surgery (except aspirin); 8. Infection near the expected injection site; 9. Ongoing sepsis; 10. Patients who have been included in the trial but need to return to the operating room for new abdominal surgery after surgery; 11. Pregnant or breastfeeding.

Design outcomes

Primary

MeasureTime frame
Quality of recovery on postoperative day 1(POD 1);

Secondary

MeasureTime frame
Quality of recovery on postoperative day 2and day 3;Pain scoreo in recovery room ;Worst pain score;Anesthesia-related discomfort (nausea and/or vomiting, drowsiness, chills, itching) ;Patient satisfaction;Time of tracheal tube removal;Number of postoperative pain treatments;Postoperative pulmonary complications;respiratory depression after operation;Total consumption of opioids;Postoperative mobility;postoperative antiemetics (number of doses);

Countries

China

Contacts

Public ContactWang Danfeng

Fuzhou University Affiliated Provincial Hospital

251487848@qq.com+86 139 0692 0551

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026