elderly patients undergoing abdominal surgery
Conditions
Interventions
Ciprofol group:The application of ciprofol throughout anesthesia maintenance
Desflurane group:The application of desflurane throughout anesthesia maintenance
Sevoflurane group:The application of sevoflurane throughout anesthesia maintenance
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2. ASA classification I-III; 3. Scheduled for elective abdominal surgery = 2 hours under general anesthesia and expected to be extubated.
Exclusion criteria
Exclusion criteria: 1. History of myocardial infarction, cardiac failure (NYHA Class III-IV) within 3 months, acute respiratory distress syndrome within 3 months, cerebral infarction within 3 months or severe chronic obstructive pulmonary disease; 2. Known allergies or contraindications to eggs, soy products or study drugs (ciprofol, rocuronium bromide, etc.); 3. With mental illness, long-term use of psychoactive drugs or cognitive dysfunction; 4. History of chronic pain or substance abuse, including alcohol, opioids, or other psychotropic substances; 5. Unable to communicate due to aphasia, severe hearing impairment or other difficulties; 6. Participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Major surgical complications;Pain scores at rest and during movement;Days Alive at home in the 30 days after Surgery;awakening time;Postoperative Hospital Stay;The incidence of severe nausea and vomiting;The time of first flatus and defecation;Total amount of rescue opioid analgesics;Quality of recovery;The incidence of hyoxemia;Incidence of Delirium; | — |
Countries
China
Contacts
Public ContactXuefei Li
West China Hospital, Sichuan University
Outcome results
None listed