Myocardial injury
Conditions
Interventions
Active taVNS Group:Participants in the ta-VNS group underwent stimulation of the left cymba conchae. Stimulation parameters were set as follows: frequency 25 Hz, pulse width 250 µs, with a duty cycle
Sham taVNS Group:Participants in the sham stimulation group followed the same intervention protocol as the ta-VNS group
however, the electrical stimulation device was turned off after the intensity adjustment procedure. All devices were labeled to ensure that each participant used the same device for every session. Par
Sponsors
Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age>=40 and <=85 years; 2. ASA classification I–III; 3. Planned isolated selective coronary artery bypass grafting (CABG) under CPB with general anesthesia; 4. NYHA cardiac function classification I–III; 5. Voluntarily participating in this study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency coronary artery bypass graft surgery; 2. Left ventricular ejection fraction (LVEF) 0.3 µg/kg/min); 8. Recent cerebrovascular accident (< 6 months); 9. Seizure or syncope recurrence in the past 5 years; 10. Patients who received vagus nerve stimulation or acupuncture treatment within 1 month before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cTn level at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immediate postoperative cTn level;cTn level at 72 hours postoperatively;Postoperative NT-proBNP levels;Creatine kinase-MB (CK-MB);Inflammatory markers; | — |
Countries
China
Contacts
Public ContactYali Ge
Nanjing First Hospital
Outcome results
None listed