Sepsis-Associated Cardiogenic Shock
Conditions
Interventions
Conventional therapy group:infection control, fluid management, vasopressors, and inotropes (according to the Surviving Sepsis Campaign 2021 Guidelines). If clinical deterioration occurs, escalation t
IABP group:conventional therapy plus IABP support
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–80 years; 2. Diagnosis of sepsis (Sepsis-3.0): infection + ?SOFA >= 2; 3. Diagnosis of cardiogenic shock, defined by: (1) Hemodynamics: cardiac index = 0.1 µg/kg/min and dobutamine >= 5 µg/kg/min; or systolic blood pressure = 0.1 µg/kg/min and dobutamine >= 5 µg/kg/min, plus LVEF = 2 mmol/L; (3) Hypovolemia excluded (CVP >= 7 mmHg).
Exclusion criteria
Exclusion criteria: 1. Acute myocardial infarction (ruled out by ECGs more than 2 hours, coronary CT, or coronary angiography); 2. Moderate to severe aortic valve insufficiency; 3. Ruptured aortic sinus aneurysm; 4. Aortic diseases such as aortic dissection, aortic aneurysm, or aortic trauma; 5. Severe peripheral vascular disease; 6. Severe active bleeding and hemorrhagic disorders; 7. End-stage disease; 8. Any other condition deemed unsuitable for this trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters;Duration of hemodynamic stability within each 24-hour period (defined as continuous MAP = 65 mmHg);Catecholamine index (CAI) ;Duration of catecholamine therapy;SOFA score (cardiovascular component);Inflammatory markers (CRP, PCT);Lactate levels;ICU length of stay;duration of mechanical ventilation;APACHE II score;Need for renal replacement therapy;Escalation to VA-ECMO; | — |
Countries
China
Contacts
Public ContactXianghong Yang
Zhejiang Provincial People's Hospital
Outcome results
None listed