Non wheezing refractory pneumonia in children
Conditions
Interventions
Research Group 1:BAL+Injecting Acetylcysteine Solution for Inhalation under bronchoscopy
Research Group 2:BAL+Injecting Ambroxol Hydrochloride Solution for Inhalation under bronchoscopy
Control Group:BAL
Sponsors
Guangzhou Panyu District Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.The diagnostic criteria of refractory pneumonia: pneumonia that has not achieved obvious clinical efficacy or ideal results after comprehensive and effective measures have been taken for pulmonary infection is called refractory pneumonia, including (1) some severe pneumonia with poor efficacy, (2) pneumonia that has not been cured for a long time, and (3) pneumonia with slow absorption. Among them: 1) Severe pneumonia refers to severe ventilation and/or gas exchange dysfunction or extrapulmonary complications; 2) Prolonged disease course (> 2 weeks), refractory to active treatment and deterioration; 3) Slow absorption refers to the patients whose symptoms and signs were improved after the use of anti-infective drugs, but the pulmonary pathological examination after 2 weeks showed that the absorption of lesions was less than 50%; 2. Airway foreign body and congenital pulmonary dysplasia were excluded by fiberoptic bronchoscopy; 3. Informed consent was obtained from the parents.
Exclusion criteria
Exclusion criteria: (1) patients with wheezing/wheezing symptoms or signs; (2) severe cardiopulmonary dysfunction; (3) severe arrhythmia; (4) high fever; (5) patients with active hemoptysis; (6) severe hemorrhagic disease; (7) coagulation dysfunction; Severe pulmonary hypertension and may induce massive hemoptysis; (8) patients with severe malnutrition who could not tolerate surgery; (9) allergic to investigational drugs; (10) other serious adverse reactions and complications, which were difficult to continue treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hot annealing time;Lung rale disappearance time;Interleukin-6 ;Interleukin-10;Tumor Necrosis Factor-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cluster of Differentiation 3+;Cluster of Differentiation 4+;Cluster of Differentiation 8+; | — |
Countries
China
Contacts
Public ContactCai Jierong
Guangzhou Panyu District Central Hospital
Outcome results
None listed