Evaluate the effects of propofol or cipepofol on the hemodynamic changes in elderly patients during the anesthesia induction period, specifically focusing on the changes in blood pressure and heart rate within 10 minutes after administration
Conditions
Interventions
3. Administration of rocuronium 0.6 mg/kg once MOAA/S score <=1
Cyclopropofol group:1. Intravenous administration of fentanyl 2.5 µg/kg
2. Infusion of HSK3486 0.4 mg/kg over 4 minutes, with an additional 0.2 mg/kg if needed
maintain anesthesia with sevoflurane after successful intubation, and supplement with fentanyl and/or HSK3486 as required.
Propofol group:1. Intravenous administration of fentanyl 2.5 µg/kg
2. Infusion of propofol 1.5 mg/kg over 4 minutes, with an additional 1 mg/kg if needed
maintain anesthesia with sevoflurane after successful intubation, and supplement with fentanyl and/or propofol as required.
Sponsors
Zhongshan Hospital ( Xiamen ) , Fudan University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Scheduled non-cardiac surgery; 2.No gender restrictions. Age 65 -85 years old; 3.A tracheal intubation is required for the induction of general anesthesia. 4.ASA I-III grades; 5.Voluntarily participate and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. BMI=30 kg·m^-2; 2. History of cerebral, thoracic, or abdominal aortic aneurysm; 3. Allergy to any drug administered in the study; 4. History of severe liver impairment, i.e., Child-Pugh Class C; 5. Currently undergoing maintenance dialysis; 6. Congestive heart failure, i.e., New York Heart Association (NYHA) Class III or IV; 7. Untreated or unstable ischemic heart disease; 8. History of severe aortic or mitral valve disease; 9. History of frequent premature ventricular contractions, frequent premature atrial contractions, or atrial fibrillation; 10. Use of antidepressant or antipsychotic medications; 11. Mean arterial pressure (MAP) <70 mmHg prior to anesthesia induction; 12. Presence or anticipated difficulty in airway management.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare the incidence of post-anesthesia hypotension (PIH) in the two groups of patients after general anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum heart rate after loss of consciousness induced by anesthesia;Maximum MAP after tracheal intubation;Assess the incidence of injection pain using a four-point scale;Total dose of anesthetic induction agents (propofol, cipepofol), frequency and total dose of vasoactive drugs.;Time from the start of anesthesia to loss of consciousness;Compare the AUC of MAP below or above baseline within the first 10 minutes after drug administration in two groups of patients (AUCMAP-, AUCMAP+) and the AUC of HR below or above 10% of baseline (AUCH;Incidence of intraoperative awareness assessed at 24-hour postoperative follow-up.;Cardiovascular complications prior to discharge (myocardial ischemia, acute myocardial infarction, heart failure, severe arrhythmias, etc.).;Incidence of postoperative delirium at 24 hours.; | — |
Countries
China
Contacts
Public ContactLiu.Juanlan
Zhongshan Hospital ( Xiamen ) , Fudan University
Outcome results
None listed