Ischemic stroke
Conditions
Interventions
vascular recanalization therapy combined with oral nano selenium capsules:oral nano selenium capsules
vascular recanalization therapy:none
Sponsors
Zhuhai People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Clinically diagnosed with acute ischemic stroke; 2.Occlusion of large vessels in the anterior or posterior circulation; 3.CT excludes intracranial hemorrhage; 4.NIHSS>=6; 5.Age >= 18 years old; 6.Signed written informed consent;
Exclusion criteria
Exclusion criteria: 1.mRS>2 before stroke; 2.Blood pressure>185/110 mmHg; 3.blood sugar22.2 mmol/L; 4.Cerebral infarction within the previous 6 weeks, with neurological deficits or neuroimaging showing signs of recent infarction; 5.History of major head trauma in the past 3 months; 6.Major surgery or severe trauma within the last 2 weeks; 7.Gastrointestinal or urinary bleeding in the past 3 weeks; 8.previous intracranial hemorrhage; 9.Use of anticoagulants, INR > 1.7 or 48 hours of oral administration of new anticoagulants; 10.Known platelet count<100 x 109/L;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS Score;Changes in the expression levels of oxidative stress markers (ROS, MDA, SOD, 12-HETE) in peripheral blood;Mortality within 45 days;Changes in blood selenium content and expression of related selenoenzymes (GPx1-4, TrxR, SEPP).; | — |
Countries
China
Contacts
Public ContactYu Liu
Zhuhai People's Hospital
Outcome results
None listed