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Protective effect of adenosine disodium triphosphate anterior chamber perfusate on corneal endothelium after phacoemulsification:A prospective randomized controlled trial

Protective effect of adenosine disodium triphosphate anterior chamber perfusate on corneal endothelium after phacoemulsification

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500113292
Enrollment
Unknown
Registered
2025-11-26
Start date
2025-11-26
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract

Interventions

N3:Adenosine disodium triphosphate group:Anterior chamber perfusate containing 0.1mg/ml adenosine disodium triphosphate was used
N4-5:Adenosine disodium triphosphate group:Anterior chamber perfusate containing 0.1mg/ml adenosine disodium triphosphate was used.
N3:The control group:Conventional anterior chamber perfusate was used.
N4-5:The control group:Conventional anterior chamber perfusate was used.

Sponsors

Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Older than 18 years old 2. Patients with lens nucleus hardness of 3-5 according to the Emery-Little grading system, who are scheduled for cataract surgery; Patients scheduled for cataract surgery 3. The operation was successful without complications such as posterior capsule rupture 4. Participants were of any gender or race 5. Participants were required to have relatively good general health to ensure the safety and feasibility of the surgical procedure 6. Participants should be willing to undergo preoperative evaluation and cooperate with postoperative follow-up observation

Exclusion criteria

Exclusion criteria: 1. Patients with a history of severe allergies. 2. Patients with serious systemic diseases requiring general anesthesia or comfortable anesthesia. 3.Patients with history of other ocular diseases, trauma and surgery.

Design outcomes

Primary

MeasureTime frame
Endothelial cell density;Central corneal thickness;

Secondary

MeasureTime frame
Best corrected visual acuity;Intraocular pressure;Slit-lamp examination;

Countries

China

Contacts

Public ContactQu Chao

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

lucyqujefferson@qq.com+86 189 8183 8603

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026