None
Conditions
Interventions
Cyclopofol 0.8µg/ml effect-site target-controlled concentration group:Anesthesia was induced with cyclopofol at a target effect-site concentration of 0.8µg/ml
Cyclopofol 0.6µg/ml effect-site target-controlled concentration group:Anesthesia was induced with cyclopofol at a target effect-site concentration of 0.6µg/ml
Cyclopofol 1.0µg/ml effect-site target-controlled concentration group:Anesthesia was induced with cyclopofol at a target effect-site concentration of 1.0µg/ml
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-III grade, aged 18-80 years old 2. Surgeries requiring the placement of artificial airways under general anesthesia (including nasopharyngeal ventilation ducts, laryngeal masks, and tracheal tubes) 3. The anesthesia method is total intravenous anesthesia 4. The expected operation duration is more than half an hour, and BIS monitoring can be achieved during the operation 5. Be willing to participate in this trial and sign a written informed consent form
Exclusion criteria
Exclusion criteria: 1. Allergic to the drugs related to the experiment 2. Central nervous system diseases, poor state of consciousness, brain surgery, surgery requiring nerve stimulation, or inability to monitor BIS during surgery 3. Before the operation, there are already or are expected to be significant conditions that may affect drug metabolism during the operation (including but not limited to: massive blood loss, hypothermia, heart failure, multiple organ failure, shock, rapid deterioration of liver and kidney functions, etc.) Sedatives such as midazolam, sevoflurane and dexmedetomidine were used during the induction and maintenance of anesthesia 5. The researchers believe there are other circumstances that make participation unsuitable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The CeLoC/CeRoC, Cp, Ke0 and actual values were calculated; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of bradycardia;Incidence of hypotension;Incidence of intraoperative awareness;Incidence of respiratory depression;Area under the blood pressure-time curve during drug administration;The quality of induction and maintenance of general anesthesia; | — |
Countries
China
Contacts
Public ContactGuo Chen
West China Hospital of Sichuan University
Outcome results
None listed