Schizophrenia, depression, bipolar disorder, anxiety disorder
Conditions
Interventions
Schizophrenia group:None
Depression group:None
healthy control group:None
Sponsors
Xijing Hospital, the Fourth Military Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 65 Years
Inclusion criteria
Inclusion criteria: Schizophrenia group 1. With the approval of the ethics committee, all participants (or guardians) shall sign a written informed consent form; 2. 200 patients with schizophrenia or schizophrenia like disorders who meet the DSM-5 diagnostic criteria; The total score of the Positive and Negative Syndrome Scale (PANSS) is >= 60 points; Age range: 13-65 years old; 3. Not using prebiotics, probiotics, and probiotic fermented foods within one month; 4. Not using any antibiotics within one month. Depression group 1. With the approval of the ethics committee, all participants (or guardians) shall sign a written informed consent form; 2. 200 patients with major depressive disorder who meet the DSM-5 diagnostic criteria; Hamilton Depression Rating Scale (HAMD) score >= 18 points; Age range: 13-65 years old; 3. Not using prebiotics, probiotics, and probiotic fermented foods within one month; 4. Not using any antibiotics within one month. Anxiety disorder group 1. With the approval of the ethics committee, all participants (or guardians) shall sign a written informed consent form; 2. 200 anxiety disorder patients who meet the DSM-5 diagnostic criteria; Hamilton Anxiety Scale (HAMA) score >= 14 points; Age range: 13-65 years old; 3. Not using prebiotics, probiotics, and probiotic fermented foods within one month; 4. Not using any antibiotics within one month. Bipolar disorder group 1. With the approval of the ethics committee, all participants (or guardians) shall sign a written informed consent form; 2. 200 patients with bipolar disorder who meet the DSM-5 diagnostic criteria (including current depressive episodes, hypomanic/manic episodes); During a depressive episode (HAMD) score >= 18 points; During manic episodes, the Young's Mania Scale (YMRS) score is >= 20 points; Age range: 13-65 years old; 3. Not using prebiotics, probiotics, and probiotic fermented foods within one month; 4. Not using any antibiotics within one month. Healthy control group 1. With the approval of the ethics committee, all participants (or guardians) shall sign a written informed consent form; 2. 100 healthy individuals aged 13-65 years old; 3. Not using prebiotics, probiotics, and probiotic fermented foods within one month; 4. Not using any antibiotics within one month.
Exclusion criteria
Exclusion criteria: 1. Presence of the following diseases: Gastrointestinal diseases: Inflammatory bowel disease, Crohn's disease, pancreatitis, fatty liver, etc. Coronary heart disease. Systemic autoimmune diseases (e.g., systemic lupus erythematosus, Behçet's disease, multiple sclerosis, connective tissue diseases). Atopic diseases (e.g., moderate to severe asthma, eczema, gastrointestinal eosinophilic disorders). Chronic pain syndromes (e.g., chronic fatigue syndrome, fibromyalgia). Neurological/neurodevelopmental disorders. 2. Obesity or metabolic abnormalities: Obesity: BMI >= 28.0. Hyperglycemia: Fasting plasma glucose (FPG) >= 6.1 mmol/L and/or 2-hour postprandial glucose (2hTC) >= 7.8 mmol/L and/or individuals who have been treated for diabetes. Hypertriglyceridemia: Triglycerides (TG) >= 2.3 mmol/L. Hypertension: Systolic blood pressure >= 140 mmHg or diastolic blood pressure >= 90 mmHg. 3. Pregnant or breastfeeding women. 4. Individuals with special dietary or lifestyle preferences. 5. Presence of other psychiatric disorders that meet the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). 6. Use of any psychotropic medications or antipyretic analgesics within the past 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diversity of gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale (HAMA);blood metabolomics;positive and negative syndrome scale;Hamilton Depression Scale;Yang's Mania Scale; | — |
Countries
China
Contacts
Public ContactPeng Zhengwu
Xijing Hospital, the Fourth Military Medical University, Xi'an, China
Outcome results
None listed