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Study on the 5mC/5hmC Modifications of NMDA Receptor Genes Involved in the Impact of Sensitive Period Adversity on Adolescent Depressive Symptoms and Their Developmental Trajectories

Study on the 5mC/5hmC Modifications of NMDA Receptor Genes Involved in the Impact of Sensitive Period Adversity on Adolescent Depressive Symptoms and Their Developmental Trajectories

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113257
Enrollment
Unknown
Registered
2025-11-26
Start date
2025-05-13
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Exposure group and Non-exposure group:None

Sponsors

Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
11 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1. Voluntary participation in this survey. 2. Aged between 11 and 18 years. 3. No major mental illness or intellectual disability, able to fully understand the purpose and process of the survey. 4. Voluntarily sign the informed consent form, agreeing to participate in baseline and follow-up surveys and provide biological samples. 5. The exposed group includes adolescents who reported experiencing childhood or recent adverse experiences in the baseline survey, while the non-exposed group includes those who did not report any childhood or recent adverse experiences in the baseline survey.

Exclusion criteria

Exclusion criteria: 1. Diagnosed with mental disorders (such as bipolar disorder, autism) or intellectual disability. 2. Diagnosed with organic disorders (such as secondary depressive disorders caused by organic diseases or medication) or a history of epilepsy. 3. Other diseases that are not suitable for participation in this study.

Design outcomes

Primary

MeasureTime frame
Depressive symptoms;

Secondary

MeasureTime frame
Anxiety symptoms;

Countries

China

Contacts

Public ContactGuo Lan

Sun Yat-sen University

guolan3@mail.sysu.edu.cn+86 151 1209 2590

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026