Septic shock
Conditions
Interventions
The group experiencing immediate temperature drop at the peak:The temperature will drop sharply at once.
Conventional cooling group:Regular cooling down
Peak Delay Cooling Group:Peak period with delayed cooling
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adults aged 18 years or older; 2. Admitted to the intensive care unit (ICU); 3. Diagnosed with septic shock according to Sepsis 3.0 criteria: suspected or documented infection; SOFA score >= 2; c. requiring vasopressors to maintain mean arterial pressure (MAP) >= 65 mmHg and lactate >= 2 mmol/L after adequate fluid resuscitation; 4. Body temperature >= 38.3?; 5. Able to sign informed consent, or have it signed by an authorized representative or close relative.
Exclusion criteria
Exclusion criteria: 1. Refusal of the experimental protocol; 2. Inability to monitor bladder temperature; 3. Very low probability of survival, defined as an expected mortality rate exceeding 95% based on the APACHE II score; 4. Having acquired immunodeficiency syndrome (according to the CDC report, classified as stage 3) and receiving immunosuppressive therapy or long-term corticosteroid treatment; 5. After traumatic brain injury or cardiac arrest resuscitation; 6. Pregnancy; 7. Active tumor stage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vasopressor positive inotropic score; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality rate;28-day length of stay in the ICU;Immune marker levels;The number of days without using a ventilator within 28 days; | — |
Countries
China
Contacts
Public ContactYin Changlin
The First Affiliated Hospital of Army Medical University
Outcome results
None listed