A randomized controlled study of intermittent theta rhythm stimulation combined with acupuncture in the treatment of upper limb motor dysfunction after ischemic stroke

A Randomized Controlled Study of Intermittent Theta Rhythm Stimulation Combined with Acupuncture for Treating Upper Extremity Motor Dysfunction After Ischemic Stroke: A Multimodal Assessment Based on Neuroplasticity Mechanisms

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500113246

Enrollment

Unknown

Registered

2025-11-26

Start date

2025-12-01

Completion date

Unknown

Last updated

2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper limb motor dysfunction in patients with ischemic stroke

Interventions

Control group 2:Routine rehabilitation

experimental group:Intermittent theta rhythm stimulation

Control group 1:Pseuditocrenic theta rhythm stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for ischemic stroke, confirmed by CT/MRI. 2. First onset, the course of the disease is 7 days (subacute stage). 3. Age 18-80 years. 4. Unilateral hemiparesis with upper limb Brunnstrom stage III-V. 5. Modified Rankin Scale (mRS) score of 1-3 points. 6. Mini-Mental State Examination (MMSE) >= 24 points. 7. Signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Unstable or progressive stroke. 2. Severe cognitive impairment or aphasia interfering with cooperation. 3. Severe heart, liver and kidney insufficiency. 4. Contraindications to TMS such as implanted metal objects and pacemakers in the body. 5. Patients who are pregnant or have a history of epilepsy. 6. Contraindications to acupuncture treatment. 7. Participation in other clinical trials at the same time.

Design outcomes

Primary

Measure	Time frame
wolf motor function test, WMFT;	—

Secondary

Measure	Time frame
upper limb motor ability;Modified Barthel Index, MBI;9-HPT;Motor Activity Log, MAL;MEP;Cortical Silent Period, CSP;Motor Threshold, MT;	—

Countries

China

Contacts

Public ContactHou Guangwen

Beijing Friendship Hospital Pinggu Campus,Capital Medical University

micky6669@163.com+86 10 8999 9014

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026